PATIENT DETAILS
Date of Birth
March 19, 1967
Chronological Age
58 years
Assessment Date
October 2, 2025
Anthropometrics
163 cm (5'4") • 58.0 kg (128 lb) • BMI 21.83 kg/m²
Menopause Status
Postmenopausal (age 55)
Next Biody (3 months)
January 2, 2026
Next REMS (6 months)
April 2, 2026
Biological vs Chronological Age
Legend: Green = at or better than chronological age • Yellow = mildly accelerated • Red = significantly accelerated
EXECUTIVE SUMMARY
Critical Findings
Left femoral neck osteoporosis (T-score −2.5)
Osteopenia in spine and right hip
Sarcopenia risk: ASMI buffer 0.99 kg/m²
Significant Findings
Cellular vitality at lower threshold
Body composition imbalance
MONW phenotype despite normal BMI
Positive Indicators
Normal hydration status
Adequate protein mass
No acute inflammation
Overall Assessment: Patient presents with accelerated musculoskeletal aging requiring immediate intervention to prevent fracture risk progression and functional decline. Prognosis is favorable with comprehensive treatment adherence.
BONE HEALTH ASSESSMENT
Spine (L1–L4) — REMS Densitometry
Bone Mineral Density (BMD)
- Total BMD: 0.842 g/cm²
- T-score: −1.9 (Osteopenia)
- Z-score: −0.6 (within expected range for age)
Fragility Score
25.1/100
Green = normal • Yellow = borderline • Red = degraded
R3 Risk Class — 5-year major osteoporotic fracture: 1.0-2.0%
Bone Mineral Content (BMC)
Measured: 2.22 kg
Reference: 2.05 kg
+8.3%
Summary (Spine): Mineral deficit (T-score −1.9) with preserved microarchitecture (Fragility 25.1). This dissociation indicates primary mineral loss rather than structural deterioration, suggesting excellent treatment response potential.
Right Femur — REMS Densitometry
Bone Mineral Density (BMD)
- Neck: 0.593 g/cm² (T-score −2.3, Osteopenia)
- Total: 0.699 g/cm² (T-score −2.0, Osteopenia)
- Trochanter: 0.722 g/cm² (T-score −1.6, Osteopenia)
Fragility Score
19.1/100
Green = normal • Yellow = borderline • Red = degraded
R4 Risk Class — 5-year hip fracture: 0.8-1.5%
Summary (Right Hip): Bilateral femoral osteopenia with lower fragility score (19.1) indicating better preserved hip architecture than spine. Normal bone quality despite reduced density.
Left Femur — REMS Densitometry
Bone Mineral Density (BMD)
- Neck: 0.575 g/cm² (T-score −2.5, Osteoporosis)
- Total: 0.678 g/cm² (T-score −2.2, Osteopenia)
- Trochanter: 0.700 g/cm² (T-score −1.7, Osteopenia)
Fragility Score
19.4/100
Green = normal • Yellow = borderline • Red = degraded
R4 Risk Class — 5-year hip fracture: 0.8-1.5%
Summary (Left Hip): WHO diagnostic threshold for osteoporosis reached in left femoral neck (T-score −2.5). Similar fragility score (19.4) to right hip indicates maintained bone quality. Left-right asymmetry suggests mechanical loading differences.
Combined Bone Health Summary: Mixed osteopenia and osteoporosis with bilateral femoral involvement more severe than spinal. Critical distinction: while BMD is reduced (quantitative deficit), preserved Fragility Scores (19.1-25.1) indicate maintained bone microarchitecture quality (qualitative preservation). This dissociation suggests primary mineral loss rather than structural deterioration, indicating better treatment response potential and lower fracture risk than BMD alone would suggest. Immediate intervention required to prevent progression.
BODY COMPOSITION ANALYSIS
Fat Mass Assessment
Total Fat Mass
13.17 kg (22.95% at constant hydration)
Body Fat Percentage
32.6%
Fat Mass Index (FMI)
4.98 kg/m²
Age-Specific Classification
Fit (31-34% for age 55-59)
Muscle Mass Assessment
Skeletal Muscle Mass (SMM)
23.26 kg (40.10% of body weight)
ASMI (Appendicular SMI)
6.69 kg/m²
Sarcopenia Threshold
<5.70 kg/m²
Safety Margin
+0.99 kg/m² (17.4% above threshold)
Body Mass Index (BMI)
21.83
Normal Weight
Underweight • Slim • Fit • Overweight • Obese
Note:
BMI has limitations as it doesn't distinguish muscle from fat. Body composition analysis provides more accurate health assessment.
Body Composition Summary: Despite normal BMI (21.83 kg/m²), patient exhibits "metabolically obese normal weight" (MONW) phenotype with elevated body fat (32.6%) and minimal sarcopenia buffer (0.99 kg/m² above threshold). While fat percentage is within "fit" range for age, the unfavorable muscle-to-fat ratio and narrow safety margin above sarcopenia threshold require immediate intervention. Annual muscle loss of 1-2% without intervention could reach sarcopenia threshold within 4-8 years.
CELLULAR HEALTH & HYDRATION
Phase Angle (50 kHz)
6.8° (Normal threshold: >6.0°)
Total Body Water (TBW)
33.53 L (57.82% of body weight)
Intracellular Water (ICW)
20.02 L (59.71% of TBW)
Extracellular Water (ECW)
13.51 L (40.29% of TBW)
ECW/TBW Ratio
40.29% (Normal: 39-45%)
Fat-Free Mass Hydration
74.80% (Normal)
Cellular Health Summary: Phase angle of 6.8° indicates adequate cellular membrane integrity but positions at lower acceptable threshold, suggesting suboptimal cellular function with room for improvement. Hydration status is well-balanced with no evidence of fluid retention or dehydration. Normal ECW/TBW ratio (40.29%) indicates absence of acute inflammation. The suboptimal phase angle may reflect mitochondrial dysfunction, a hallmark of biological aging, responding well to targeted nutritional intervention (CoQ10, PQQ, NAC) and exercise.
METABOLIC ASSESSMENT
Basal Metabolic Rate (BMR)
1,254 kcal/day
Reference BMR
1,222 kcal/day
Deviation
+32 kcal/day (+2.6%)
Sedentary (maintenance)
1,545 kcal/day
Moderate Activity (3-5×/week)
1,996 kcal/day
Very Active (6-7×/week)
2,221 kcal/day
Metabolic Summary: BMR slightly elevated (+2.6%) compared to reference, indicating adequate muscle mass and no metabolic suppression. For body recomposition goals (fat loss with muscle preservation), recommended caloric intake of 1,400-1,600 kcal/day with moderate exercise creates appropriate deficit for 0.5-1 kg/month fat loss. Protein requirement: 90-110 g/day (1.6-1.9 g/kg lean body mass) distributed across 3 meals. Despite normal BMI, elevated fat percentage warrants screening for metabolic syndrome components (insulin resistance, dyslipidemia, inflammatory markers).
CLINICAL RECOMMENDATIONS
Immediate Actions Required
- Bone Health: Initiate osteogenic loading therapy (Biodensity 1×/week) + vitamin D3 (2,000-4,000 IU), K2-MK7 (100-200 mcg), calcium hydroxyapatite (1,000 mg), magnesium glycinate (300-400 mg)
- Muscle Preservation: Progressive resistance training 2-3×/week + protein optimization 90-110g daily + EAA supplementation (15g post-training) + creatine monohydrate (5g daily)
- Body Recomposition: Low-carb Mediterranean diet + 16:8 intermittent fasting + moderate aerobic activity 150-200 min/week
- Cellular Health: CoQ10 (100-200mg), PQQ (20mg), NAC (600-1,200mg), Omega-3 (2-3g EPA+DHA daily)
- Laboratory Assessment: Bone turnover markers (CTX, P1NP), vitamin D, inflammatory markers (hs-CRP), metabolic panel (glucose, insulin, HbA1c, lipids), hormone panel
12-Week Goals
Fat mass: −1.5-2.5 kg
ASMI: Stable or increased
Strength: +15-25%
Phase angle: Improve toward 7.0°+
12-Month Goals
BMD: +2-5% improvement
ASMI: >7.0 kg/m²
Body fat: <30%
Biological age: −2-3 years
Monitoring Schedule
Week 12: Biody reassessment
Month 6: REMS + labs
Month 12: Comprehensive review
Quarterly: Functional testing
PROGNOSIS & OUTCOMES
With Full Adherence (Best Case)
12-Month Outcomes:
• BMD improvement: 3-5%
• ASMI: Increased to 7.0-7.3 kg/m²
• Body fat: Reduced to 28-30%
• Phase angle: 7.0-7.5°
• Fracture risk: Reduced to R2-R3
• Biological age: −2-3 years
• Quality of life: Significantly improved
70-80% Adherence (Realistic)
12-Month Outcomes:
• BMD: Stable or +1-2%
• ASMI: Maintained above 6.5 kg/m²
• Body fat: Reduced to 30-31%
• Phase angle: 6.9-7.2°
• Fracture risk: Stable
• Biological age: −1 year
Without Intervention
12-24 Month Trajectory:
• BMD decline: 1-2% annually
• Progression to osteoporosis
• Muscle loss: 1-2% annually
• ASMI: Approaching sarcopenia
• Body fat: Increased to 34-36%
• Fracture risk: Escalation to R5-R6
• Accelerated biological aging
Key Success Factors: Patient has significant positive prognostic factors including normal fragility scores (preserved bone quality), adequate current muscle mass, and normal hydration. The critical distinction between reduced BMD but preserved bone microarchitecture indicates excellent treatment response potential. Consistent adherence to resistance training, adequate protein intake, Biodensity program, and supplement protocol are essential for optimal outcomes.